Sleep research article
Home-based exercise interventions incorporating cardiac rehabilitation principles for people with cancer: a systematic review and meta-analysis.
Authors: Winnige P , Dosbaba F , Hartman M , Pepera G , Antoniou V , Karagianni E , Perone F , Lin R , Su JJ , Batalik L
One-line summary
A sleep science research article on Home-based exercise interventions incorporating cardiac rehabilitation principles for people with cancer: a systematic review and meta-analysis..
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Original abstract
<h4>Background</h4>People with cancer are at increased cardiovascular risk due to treatment-related cardiotoxicity and shared risk factors. Exercise-based cardiac rehabilitation (exCR) may mitigate these risks, but access to center-based programs is limited. This systematic review and meta-analysis evaluated the effectiveness, safety, and adherence of home-based exCR in oncology populations.<h4>Methods</h4>Six databases were searched in January 2025 for randomized controlled trials (RCTs) of home-based exCR in adults with cancer. Eligible interventions included structured aerobic and/or resistance exercise consistent with established CR guidelines. Primary outcomes were cardiorespiratory fitness (CRF), health-related quality of life (HRQoL), adherence, and safety. Random-effects meta-analyses used standardized mean differences (SMDs).<h4>Results</h4>Nine RCTs (632 participants) were included. Home-based exCR improved CRF (SMD 0.42; 95% CI 0.09-0.75; <i>I</i>²=62%) and HRQoL (SMD 0.63; 95% CI 0.05-1.22; <i>I</i>²=84%). TESTEX scores indicated generally good methodological and reporting quality (mean 10/15; range 7-13). Adherence exceeded 75% in most studies reporting this outcome, and dropout was 15.2%. Adverse-event reporting was inconsistent; no clear safety signal emerged, but evidence was insufficient for firm conclusions. Strength and fatigue findings were inconsistent.<h4>Conclusions</h4>Home-based exCR appears feasible and may improve CRF and HRQoL in people with cancer, offering an accessible alternative or complement to center-based rehabilitation. Incomplete adverse-event reporting limits safety conclusions. Future studies should evaluate full, multi-component CR models in oncology.
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