Sleep research article
Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of <i>Acampe papillosa</i> Stem Extract.
Authors: Sadia QA , Tamim ST , Tashriq FM , Uddin N , Hima FZA , Surat US , Khastagir M , Jalil MA , Rasel MH , Rafi AU , Hossen SMM
One-line summary
A sleep science research article on Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of <i>Acampe papillosa</i> Stem Extract..
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Original abstract
<i>Acampe papillosa</i>, an orchid species traditionally utilised as an herbal medicine, has yet to be extensively researched for its potential pharmacological properties. This study examined the potential for anti-anxiety, sedative, anti-inflammatory and antipyretic effects of methanol extract of the stem of <i>A. papillosa</i> (APSME) through in vivo and in silico approaches. A dose of 200 and 400 mg/kg was administered to Swiss albino rodents. When examined in the elevated plus maze, APSME-treated mice spent significantly longer periods of time in the open arms of the maze at both dosages than control animals (<i>p</i> < 0.001), indicating an anxiolytic effect of APSME. The sedative effects of APSME were assessed by measuring locomotor activity using an open field test and a hole cross test, with both methods showing a significant decrease in locomotion as APSME doses increased from 200 to 400 mg. Following treatment of rodents with carrageenan-induced paw oedema using APSME (400 mg/kg), significant reductions in the thickness of the paw were observed at 4 h post-administration compared to control groups (<i>p</i> < 0.001), indicating strong anti-inflammatory activity. Antipyretic effects of APSME were measured using a brewer's yeast-induced pyrexia animal model and were accompanied by statistically significant reductions in rectal temperature at 21 h post-treatment (98.04 ± 0.05°F). Molecular docking and PASS prediction further support these findings by showing favourable interactions between the plant phytochemicals and relevant biological targets. Overall, the results suggest that <i>A. papillosa</i> could be a promising natural source for developing treatments for anxiety, inflammation, fever and related conditions.
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