Sleep research article
Pridinol treatment in cervical dystonia: improvement of non-motor symptoms.
Authors: Becktepe JS , Baumann A , Brinker DK , Gless CA , Toedt I , Zeuner KE
One-line summary
A sleep science research article on Pridinol treatment in cervical dystonia: improvement of non-motor symptoms..
Sleep health notes
Sleep health notes will be added by the Sleepatch editorial team.
中文解读
中文解读待补充：本站会优先为失眠研究、睡眠质量改善、昼夜节律等高价值睡眠研究添加中文说明。
Original abstract
<h4>Methods</h4>This non-interventional pilot study enrolled 20 CD-patients. Pridinol mesylate was prescribed additionally to the standard botulinum toxin (BoNT)-treatment at the initial visit (V1). Follow-up visits were performed after 4 (V2) and after 12 weeks (V3). Motor and non-motor symptoms were assessed using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), the Dystonia Non-Motor Symptoms Questionnaire (DNMSQuest), the Beck Depression Inventory (BDI-II), and the EQ-5D-5L Quality of Life assessment.<h4>Results</h4>The TWSTRS part I motor score and BDI-II significantly improved from V1 to V3. The TWSTRS part III (pain) showed some effect between V1 and V2 and remained unchanged until V3. There was a significant negative correlation between the visual analog scale of the EQ-5D-5L and TWSTRS and a trend towards a positive correlation between TWSTRS part III and BDI-II.<h4>Discussion</h4>Our findings suggest, that pridinol mesylate has some additional clinical effect on motor symptoms and pain when added to BoNT-treatment.
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