Sleep-related forcing of cerebrospinal fluid streaming transport through the third ventricle

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中文解读

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Original abstract

Quasi-periodic pressure pulses associated with cardiac and respiratory activity generate reciprocating cerebrospinal fluid (CSF) motion in the human ventricles. While weak and more regular during wakefulness, oscillatory fluid motions have recently been found to be much more exaggerated during NREM sleep, appearing as large flushes in successive pulse trains. The present study investigates whether this forcing can induce greater residual streaming through the human ventricles. Transient CFD simulations were performed in the third ventricle under awake and sleep-related flow pulses. Sleep-related forcing produced clear caudal and rostral preferential pathways and less overall recirculation in the cavity. The streaming flux relative to the stroke volume increased from a low value of about \(0.540\%\) to \(28.4\%\) during sleep. Thus, sleep-related forcing changes not only the magnitude of reciprocating fluid displacement but also the relative contribution of residual streaming. These findings demonstrate differences in hydrodynamic organisation in the third ventricle and highlight the importance of this organisation for intraventricular fluid exchange.

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